Murdoch Craig, Muthana Munitta, Coffelt Seth B, Lewis Claire E
Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, Beech Hill Road, University of Sheffield, Sheffield, UK.
Nat Rev Cancer. 2008 Aug;8(8):618-31. doi: 10.1038/nrc2444. Epub 2008 Jul 17.
The use of various transgenic mouse models and analysis of human tumour biopsies has shown that bone marrow-derived myeloid cells, such as macrophages, neutrophils, eosinophils, mast cells and dendritic cells, have an important role in regulating the formation and maintenance of blood vessels in tumours. In this Review the evidence for each of these cell types driving tumour angiogenesis is outlined, along with the mechanisms regulating their recruitment and activation by the tumour microenvironment. We also discuss the therapeutic implications of recent findings that specific myeloid cell populations modulate the responses of tumours to agents such as chemotherapy and some anti-angiogenic therapies.
多种转基因小鼠模型的应用以及对人类肿瘤活检样本的分析表明，骨髓来源的髓系细胞，如巨噬细胞、中性粒细胞、嗜酸性粒细胞、肥大细胞和树突状细胞，在调节肿瘤血管形成和维持方面发挥着重要作用。在本综述中，概述了每种细胞类型驱动肿瘤血管生成的证据，以及肿瘤微环境调节其募集和激活的机制。我们还讨论了近期研究结果的治疗意义，即特定的髓系细胞群体会调节肿瘤对化疗药物和某些抗血管生成疗法等药物的反应。
