Illich P A, Salinas J A, Grau J W
Department of Psychology, Texas A&M University, College Station 77843.
Behav Neurosci. 1991 Jun;105(3):478-81. doi: 10.1037//0735-7044.105.3.478.
Previous research suggests that a stimulus that has been paired with an aversive event can elicit either an increase (hyperalgesia) or decrease (hypoalgesia) in pain reactivity in rats. Attempts have recently been made to isolate the variables that determine the direction of the conditioned response. Very little evidence has been found for conditioned hyperalgesia when a spinally mediated measure of pain reactivity (the tail-flick test) was used. In the present study, the impact of a conditioned stimulus was assessed using a procedure modeled after one in which conditioned hyperalgesia was obtained with the tail-flick test (Davis & Hendersen, 1985, Experiment 4). With this training paradigm, a discrete conditioned stimulus was found to elicit hypoalgesia but not hyperalgesia.
先前的研究表明，与厌恶事件配对的刺激可使大鼠的疼痛反应性增加（痛觉过敏）或降低（痛觉减退）。最近有人试图找出决定条件反应方向的变量。当使用脊髓介导的疼痛反应性测量方法（甩尾试验）时，几乎没有发现条件性痛觉过敏的证据。在本研究中，采用一种模仿通过甩尾试验获得条件性痛觉过敏的实验程序（Davis和Hendersen，1985年，实验4）来评估条件刺激的影响。通过这种训练范式，发现一个离散的条件刺激可引发痛觉减退而非痛觉过敏。
