性别与受伤的大脑。
Gender and the injured brain.
作者信息
Vagnerova Kamila, Koerner Ines P, Hurn Patricia D
机构信息
Department of Anesthesiology and Peri-Operative Medicine, Oregon Health and Science University, Portland, Oregon 97239, USA.
出版信息
Anesth Analg. 2008 Jul;107(1):201-14. doi: 10.1213/ane.0b013e31817326a5.
Abstract
Anesthesiologists are frequently confronted with patients who are at risk for neurological complications due to perioperative stroke or prior traumatic brain injury. In this review, we address the growing and fascinating body of data that suggests gender and sex steroids influence the pathophysiology of injury and outcome for these patients. Cerebral ischemia, traumatic brain injury, and epilepsy are reviewed in the context of potential sex differences in mechanisms and outcomes of brain injury and the role of estrogen, progesterone, and androgens in shaping these processes. Lastly, implications for current and future perioperative and intensive care are identified.
摘要
麻醉医生经常会遇到因围手术期中风或既往创伤性脑损伤而有发生神经并发症风险的患者。在这篇综述中，我们探讨了越来越多且引人入胜的数据，这些数据表明性别和性类固醇会影响这些患者的损伤病理生理学和预后。我们在脑损伤机制和预后方面潜在的性别差异以及雌激素、孕激素和雄激素在塑造这些过程中的作用的背景下，对脑缺血、创伤性脑损伤和癫痫进行了综述。最后，确定了对当前和未来围手术期及重症监护的影响。
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