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靶向骨髓间充质祖细胞用于骨再生的细胞间信号

Targeting intercellular signals for bone regeneration from bone marrow mesenchymal progenitors.

作者信息

Long Fanxin

机构信息

Department of Medicine, Department of Developmental Biology, Washington Universtiy Medical School, St. Louis, Missouri 63110, USA.

出版信息

Cell Cycle. 2008 Jul 15;7(14):2106-11. doi: 10.4161/cc.7.14.6257. Epub 2008 May 8.

DOI:10.4161/cc.7.14.6257
PMID:18635951
Abstract

There are tremendous unmet clinical needs for effective strategies to enhance bone regeneration in vivo. The sustained presence of multipotent mesenchymal progenitors in the bone marrow in aged and osteoporotic individuals offers the potential for therapeutic interventions to induce osteoblast production from the resident progenitors. Recent advances in understanding the intercellular signals governing osteogenic decisions may provide targets for developing novel bone-enhancing therapeutics.

摘要

对于增强体内骨再生的有效策略，存在着巨大未被满足的临床需求。在老年和骨质疏松个体的骨髓中，多能间充质祖细胞的持续存在为诱导驻留祖细胞产生成骨细胞的治疗干预提供了潜力。在理解调控成骨决定的细胞间信号方面的最新进展，可能为开发新型骨增强疗法提供靶点。

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