Hardy Kristina K, Bonner Melanie J, Willard Victoria W, Watral Melody Ann, Gururangan Sridharan
Duke University Medical Center, Department of Psychiatry, Durham, NC 27710, USA.
Psychooncology. 2008 Nov;17(11):1157-61. doi: 10.1002/pon.1349.
The purpose of the study was to assess the relationship between shunted hydrocephalus and intellectual, memory and academic functioning in a group of survivors of pediatric medulloblastoma.
Data from measures of cognitive, memory, academic and visual-motor functioning were gathered retrospectively from 35 survivors. Of these survivors, 10 (28.6%) required ventriculoperitoneal-shunt placement for hydrocephalus posttumor resection.
Results revealed that participants with shunted hydrocephalus demonstrated significantly lower IQs, lower nonverbal intellectual functioning, lower academic skills in writing and math, and impairments in visual-motor abilities when compared with those without shunt.
These results highlight the need to explore other variables--in addition to radiation and chemotherapy--as risk factors for neurocognitive impairments in survivors. Furthermore, identification of physiological substrates underlying these deficits is needed.
本研究旨在评估小儿髓母细胞瘤幸存者中分流性脑积水与智力、记忆及学业功能之间的关系。
回顾性收集了35名幸存者的认知、记忆、学业及视运动功能测量数据。在这些幸存者中,10名(28.6%)在肿瘤切除术后因脑积水需要进行脑室腹腔分流术。
结果显示,与未分流者相比,分流性脑积水参与者的智商显著较低,非言语智力功能较低,写作和数学方面的学业技能较低,且视运动能力受损。
这些结果凸显了除放疗和化疗外,还需探索其他变量作为幸存者神经认知障碍风险因素的必要性。此外,还需要确定这些缺陷背后的生理基础。