通过形成N-烯基炔基酰胺然后进行金催化的环异构化反应，实现取代2-吡啶酮的汇聚式快速组装。
Convergent and rapid assembly of substituted 2-pyridones through formation of N-alkenyl alkynylamides followed by gold-catalyzed cycloisomerization.
作者信息
Imase Hidetomo, Noguchi Keiichi, Hirano Masao, Tanaka Ken
机构信息
Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
出版信息
Org Lett. 2008 Aug 21;10(16):3563-6. doi: 10.1021/ol801466f. Epub 2008 Jul 18.
PMID:18636742
Abstract
A new method for the convergent and rapid assembly of substituted 2-pyridones was developed through the formation of N-alkenyl alkynylamides (amide-linked 1,5-enynes) by N-acylation of imines with alkynoyl chlorides and the subsequent cationic Au(I)/PPh 3-catalyzed cycloisomerization.
摘要
通过用炔酰氯对亚胺进行N-酰化反应生成N-烯基炔基酰胺（酰胺连接的1,5-烯炔），随后在阳离子Au(I)/PPh₃催化下进行环异构化反应，开发出了一种用于取代2-吡啶酮的收敛且快速组装的新方法。
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