精神分裂症中的阿尔法节律与额叶功能低下
Alpha rhythm and hypofrontality in schizophrenia.
作者信息
Knyazeva M G, Jalili M, Meuli R, Hasler M, De Feo O, Do K Q
机构信息
Department of Neurology, Centre Hospitalier Universitaire Vaudois and University of Lausanne and Department of Radiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
出版信息
Acta Psychiatr Scand. 2008 Sep;118(3):188-99. doi: 10.1111/j.1600-0447.2008.01227.x. Epub 2008 Jul 10.
OBJECTIVE
To reveal the EEG correlates of resting hypofrontality in schizophrenia (SZ).
METHOD
We analyzed the whole-head EEG topography in 14 patients compared to 14 matched controls by applying a new parameterization of the multichannel EEG. We used a combination of power measures tuned for regional surface mapping with power measures that allow evaluation of global effects.
RESULTS
The SZ-related EEG abnormalities include i) a global decrease in absolute EEG power robustly manifested in the alpha and beta frequency bands, and ii) a relative increase in the alpha power over the prefrontal brain regions against its reduction over the posterior regions. In the alpha band both effects are linked to the SZ symptoms measured with Positive and Negative Symptom Scales and to chronicity.
CONCLUSION
As alpha activity is related to regional deactivation, our findings support the concept of hypofrontality in SZ and expose the alpha rhythm as a sensitive indicator of it.
目的
揭示精神分裂症（SZ）静息状态下额叶功能低下的脑电图相关性。
方法
通过应用多通道脑电图的新参数化方法，我们分析了14例患者与14例匹配对照的全脑脑电图地形图。我们将针对区域表面映射调整的功率测量与允许评估全局效应的功率测量相结合。
结果
与SZ相关的脑电图异常包括：i）在α和β频段中绝对脑电图功率的整体下降，在α和β频段中表现明显；ii）前额叶脑区α功率相对于后区α功率的降低出现相对增加。在α频段，这两种效应均与用阳性和阴性症状量表测量的SZ症状以及病程相关。
结论
由于α活动与区域失活有关，我们的研究结果支持SZ中额叶功能低下的概念，并将α节律作为其敏感指标。
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