Inashkina I, Radovica I, Smeltere L, Vitols E, Jankevics E
Latvian Biomedical Research and Study Centre, Riga, Latvia.
Eur J Neurol. 2008 Sep;15(9):988-90. doi: 10.1111/j.1468-1331.2008.02225.x. Epub 2008 Jul 10.
Essential tremor (ET) is the most prevalent inherited movement disorder. ET has been mapped on chromosomes 2 and 3, but causative genes are not known.
We genotyped 16 microsatellite markers in a case-control cohort consisting of 104 patients and 116 controls.
No significant difference between allele frequencies was found. The highest difference of frequencies was found in allele 171 of the marker D2S220 (OR 0.13, 95% CI 0.02-1.03, P = 0.05). In addition, we investigated the distribution of suspected disease gene DRD3 Ser9Gly polymorphism in the same patients and controls.
There was not a significant difference in genotypic distribution between disease group and control subjects (chi2 =2.8, P = 0.25).
