Krix Martin
German Cancer Research Center, Department of Radiology, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Eur Radiol. 2005 Dec;15 Suppl 5:E104-8. doi: 10.1007/s10406-005-0172-z.
Ultrasound techniques are presented using the contrast agent SonoVue (Bracco, Italy) for microvascular imaging of liver metastases and for the detection of treatment-related changes in tumour perfusion. Technical requirements and examination protocols for contrast-enhanced ultrasound (CEUS) in the detection of microvascularity are described. Procedures for the quantitative analysis of perfusion in follow-up examinations are explained. Compared to contrast-enhanced computed tomography, low-MI (mechanical index) CEUS with SonoVue better reflected the arterial perfusion of liver metastases. Changes of tumour perfusion after stereotactic radiotherapy or chemotherapy of liver metastases could be sensitively detected using CEUS. In addition, possible changes of the liver perfusion after therapy could be assessed. Replenishment kinetics of the contrast agent allowed for a quantitative analysis of the arterial and portal venous perfusion in the tumour and the liver tissue. CEUS is a promising method to non-invasively monitor systemic or local-ablative therapies of liver metastases by sensitively detecting changes of tumour perfusion.
本文介绍了使用超声造影剂声诺维（意大利布瑞柯公司）进行肝脏转移瘤微血管成像以及检测肿瘤灌注中与治疗相关变化的超声技术。描述了在检测微血管时超声造影增强（CEUS）的技术要求和检查方案。解释了在随访检查中进行灌注定量分析的程序。与增强计算机断层扫描相比，使用声诺维的低机械指数（MI）CEUS能更好地反映肝脏转移瘤的动脉灌注情况。使用CEUS可灵敏地检测肝脏转移瘤立体定向放疗或化疗后肿瘤灌注的变化。此外，还可评估治疗后肝脏灌注的可能变化。造影剂的补充动力学允许对肿瘤和肝组织中的动脉和门静脉灌注进行定量分析。CEUS是一种很有前景的方法，可通过灵敏地检测肿瘤灌注变化来无创监测肝脏转移瘤的全身或局部消融治疗。
