Stinski M F, Petrik D T
Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA.
Curr Top Microbiol Immunol. 2008;325:133-52. doi: 10.1007/978-3-540-77349-8_8.
The IE86 protein of human cytomegalovirus (HCMV) is unique among viral and cellular proteins because it negatively autoregulates its own expression, activates the viral early and late promoters, and both activates and inhibits cellular promoters. It promotes cell cycle progression from Go/G1 to G1/S and arrests cell cycle progression at the G1/S interface or at G2/M. The IE86 protein is essential because it creates a cellular environment favorable for viral replication. The multiple functions of the IE86 protein during the replication of HCMV are reviewed.
人类巨细胞病毒（HCMV）的IE86蛋白在病毒蛋白和细胞蛋白中独一无二，因为它能负向自动调节自身表达，激活病毒早期和晚期启动子，并且既能激活也能抑制细胞启动子。它促进细胞周期从G0/G1期进入G1/S期，并使细胞周期在G1/S界面或G2/M期停滞。IE86蛋白至关重要，因为它能营造有利于病毒复制的细胞环境。本文综述了IE86蛋白在HCMV复制过程中的多种功能。
