Dennerstein Lorraine, Guthrie Janet R, Hayes Richard D, DeRogatis Leonard R, Lehert Philippe
Office for Gender and Health, Department of Psychiatry, The University of Melbourne, Victoria, Australia.
J Sex Med. 2008 Oct;5(10):2291-9. doi: 10.1111/j.1743-6109.2008.00936.x. Epub 2008 Jul 14.
Previous, population-based studies investigating the risk factors for sexual distress have not drawn on longitudinal data.
Determine the prevalence of sexual distress and dysfunction, explore factors associated with/predictive of sexual distress, and describe changes in sexual function over a decade in a population-based sample of mid-aged women.
Eleven-year prospective study of Australian-born women, aged 45-55 years, and menstruating at baseline. Short Personal Experiences Questionnaire (SPEQ) was completed in years 1 to 8 and 11 of follow-up. Female Sexual Distress Scale (FSDS) was completed in the 11th year of follow-up.
Validated outcome measures were the SPEQ (total sex score <or=7 indicates low sexual function) and FSDS (score >or=15 indicates sexual distress).
Two hundred fifty-seven women were interviewed in the 11th year of follow-up. All domains of sexual function declined significantly in the decade studied. Women using hormone therapy in year 11 had significantly greater responsivity and higher frequency of sexual activities than nonusers. Two hundred four women completed both the FSDS and SPEQ questionnaires. One hundred sixty-six (81%) women had an SPEQ score <or=7 of whom 34 (17% of the total sample) had an FSDS score >or=15, and were classified as having female sexual dysfunction. The multiple logistic regression analysis found that female sexual distress was concurrently associated with higher depression scores (odds ratio [OR] 1.31, 95% confidence interval [CI] 1.10, 1.56) and more negative feelings for partner (OR 0.49, 95% CI 0.32, 0.76) and predicted by prior negative feelings for partner (OR 0.31, 95% CI 0.14, 0.70), and a greater decline in total sex score (OR 0.77, 95% CI 0.59, 0.99).
By the end of the sixth decade, women have low levels of sexual function. Hormone therapy may help these women maintain sexual function. A minority of these mostly postmenopausal women are significantly distressed about low sexual function. Sexual distress is associated with depression and relationship factors.
以往基于人群的研究在调查性困扰的风险因素时,并未采用纵向数据。
确定性困扰和性功能障碍的患病率,探索与性困扰相关/可预测性困扰的因素,并描述在以中年女性为样本的人群中,十年间性功能的变化情况。
对出生于澳大利亚、年龄在45 - 55岁且基线时处于经期的女性进行为期11年的前瞻性研究。在随访的第1年至第8年以及第11年完成简短个人经历问卷(SPEQ)。在随访的第11年完成女性性困扰量表(FSDS)。
经过验证的观察指标为SPEQ(总性得分≤7表明性功能低下)和FSDS(得分≥15表明存在性困扰)。
在随访的第11年对257名女性进行了访谈。在所研究的十年间,性功能的所有领域均显著下降。在第11年使用激素疗法的女性比未使用者具有显著更高的反应性和更频繁的性活动。204名女性同时完成了FSDS和SPEQ问卷。166名(81%)女性的SPEQ得分≤7,其中34名(占总样本的17%)的FSDS得分≥15,被归类为患有女性性功能障碍。多元逻辑回归分析发现,女性性困扰与更高的抑郁得分(比值比[OR] 1.31,95%置信区间[CI]为1.10,1.56)以及对伴侣更多的负面感受(OR 0.49,95% CI 0.32,0.76)同时存在关联,并由先前对伴侣的负面感受(OR 0.31,95% CI 0.14,0.70)以及总性得分的更大下降(OR 0.�7,95% CI 0.59,0.99)所预测。
到第六个十年结束时,女性性功能水平较低。激素疗法可能有助于这些女性维持性功能。这些大多为绝经后女性中的少数人对性功能低下深感困扰。性困扰与抑郁及关系因素有关。