Szoeke Cassandra, Coulson Melissa, Campbell Stephen, Dennerstein Lorraine
1Department of Medicine-Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria 3050 Australia.
2Melbourne Health, Melbourne, Australia.
Womens Midlife Health. 2016 Oct 4;2:5. doi: 10.1186/s40695-016-0018-y. eCollection 2016.
The cohort was commenced to examine women's health from midlife (45-55 years) before the menopausal transition and into ageing.
Randomised selection and assessment of 2,001 women living in the Melbourne metropolitan area was conducted by the Roy Morgan Centre in 1990/91. Of the 779 women who met the entry criteria for the longitudinal follow-up (aged 45-55 years, menstruating, having a uterus and at least one ovary and not taking hormone therapy) 438 agreed to be seen annually across the menopausal transition from 1992 to 1999. Longitudinal prospective follow-up since 2000 has continued intermittently (2002/03, 2004/05, 2012/13, 2014/15). Data collection has included fasting biomarkers in each year since 1992, clinical assessment, lifestyle and quality of life data, physical measures and validated questionnaire data. Participants have consented to data linkage and, to date, mammogram and BioGrid data have been accessed. Biobank storage including serum, deoxyribonucleic acid (DNA) storage and PAXgene tubes are maintained.
The WHAP has contributed to over 200 published research findings, several books, and book chapters in a variety of areas, including: health and wellbeing; mental and cognitive health; bone health; lifestyle, vascular risk and prevention; women's health and hormonal transition; and cross-cultural research.With all participants now aged over 70 years, the cohort is ideally placed to answer key questions of healthy ageing in women. With more than 25 years of longitudinal prospective follow-up this Australian dataset is unique in its duration, breadth and detail of measures including clinical review and specialized disease-specific testing and biomarkers. Ongoing follow-up into older ages for this long-running cohort will enable the association between mid to late-life factors and healthy ageing to be determined. This is particularly valuable for the examination of chronic diseases which have a 20-30 year prodrome and to provide knowledge on multiple morbidities. The dataset has a unique opportunity to improve our understanding of temporal relationships and the interactions between risk factors and comorbidities.
该队列研究始于对处于绝经前期（45 - 55岁）直至老年期的女性健康状况进行调查。
1990/91年，罗伊·摩根中心对墨尔本市区的2001名女性进行了随机选取和评估。在符合纵向随访入选标准（年龄45 - 55岁、有月经、有子宫和至少一个卵巢且未接受激素治疗）的779名女性中，438人同意在1992年至1999年绝经过渡期间每年接受检查。自2000年起进行纵向前瞻性随访，随访工作断断续续进行（2002/03年、2004/05年、2012/13年、2014/15年）。数据收集包括自1992年起每年的空腹生物标志物数据、临床评估、生活方式和生活质量数据、身体测量数据以及经过验证的问卷数据。参与者已同意进行数据关联，截至目前，已获取了乳房X光检查和生物网格数据。生物样本库保存着血清、脱氧核糖核酸（DNA）以及PAXgene管。
女性健康与衰老项目（WHAP）已在多个领域促成了200多项已发表的研究成果、多部书籍及书中章节，这些领域包括：健康与幸福；心理和认知健康；骨骼健康；生活方式、血管风险及预防；女性健康与激素转变；以及跨文化研究。由于所有参与者目前年龄均超过70岁，该队列非常适合回答女性健康老龄化的关键问题。凭借超过25年的纵向前瞻性随访，这个澳大利亚数据集在测量的持续时间、广度和细节方面独具特色，包括临床检查以及针对特定疾病的专门检测和生物标志物。对这个长期队列持续进行老年期随访，将能够确定中年至老年因素与健康老龄化之间的关联。这对于检查有20 - 30年前驱期的慢性疾病以及提供关于多种疾病并存的知识尤为有价值。该数据集有独特的机会增进我们对时间关系以及风险因素与共病之间相互作用的理解。
