用于生物医学电子顺磁共振应用的两种持久性氟化四硫代三芳基甲基（TAM）自由基的合成。
Synthesis of two persistent fluorinated tetrathiatriarylmethyl (TAM) radicals for biomedical EPR applications.
作者信息
Driesschaert Benoît, Charlier Nicolas, Gallez Bernard, Marchand-Brynaert Jacqueline
机构信息
Unité de Chimie Organique et Médicinale, Université catholique de Louvain, UCL, place Louis Pasteur 1, B-1348 Louvain-la-Neuve, Belgium.
出版信息
Bioorg Med Chem Lett. 2008 Aug 1;18(15):4291-3. doi: 10.1016/j.bmcl.2008.06.100. Epub 2008 Jul 3.
Tetrathiatriarylmethyl radicals are attractive spin probes extensively used in biomedical magnetic resonance applications. We report a straightforward synthesis of two original tetrathiatriarylmethyl radicals incorporating, respectively, 15 and 45 fluorine atoms, and thus possessing a high affinity to fluorous media. F15T-03 and F45T-03 exhibit a single sharp EPR spectrum and their EPR line broadening is highly sensitive to molecular oxygen. These spin probes are specially designed for assessment of tumor oxygenation using perfluorocarbon formulations.
四硫代三芳基甲基自由基是极具吸引力的自旋探针，广泛应用于生物医学磁共振领域。我们报道了两种新型四硫代三芳基甲基自由基的简便合成方法，它们分别含有15个和45个氟原子，因此对氟介质具有高亲和力。F15T - 03和F45T - 03呈现出单一尖锐的电子顺磁共振（EPR）谱，并且它们的EPR谱线展宽对分子氧高度敏感。这些自旋探针是专门设计用于使用全氟化碳制剂评估肿瘤氧合情况的。
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