Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, 43210, USA.
Bioorg Med Chem Lett. 2010 Jul 1;20(13):3946-9. doi: 10.1016/j.bmcl.2010.05.006. Epub 2010 May 7.
Substituted trityl radicals are important spin probes for functional electron paramagnetic resonance spectroscopy and imaging including oxygen and pH mapping in vivo. Here we report the synthetic procedure for large scale synthesis of deuterated Finland trityl radical with superior EPR spectral properties and higher sensitivity towards oxygen concentrations in solution. Additionally Finland trityl radicals substituted with linkers suitable for attaching peptide, or other synthetic precursors have been synthesized. The effect of deutero-substitution on EPR spectra of homologous derivatives has been evaluated. The compounds are potential candidates for targeted spin probes in EPR imaging.
取代三苯甲基自由基是功能电子顺磁共振波谱和成像的重要自旋探针，包括体内氧和 pH 映射。在这里，我们报告了用于大规模合成具有优越电子顺磁共振光谱特性和对溶液中氧浓度更高灵敏度的氘代芬兰三苯甲基自由基的合成程序。此外，还合成了适合连接肽或其他合成前体的带有接头的芬兰三苯甲基自由基。已经评估了氘取代对同系物衍生物的 EPR 光谱的影响。这些化合物是 EPR 成像中靶向自旋探针的潜在候选物。
