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Functional characterization of cis-acting elements involved in basal transcription of the human Tbx2 gene: a new insight into the role of Sp1 in transcriptional regulation.

作者信息

Teng Huajian, Parker M Iqbal, Prince Sharon

机构信息

Division of Cell Biology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Observatory, 7925, Cape Town, South Africa.

出版信息

Gene. 2008 Oct 15;423(1):8-13. doi: 10.1016/j.gene.2008.06.017. Epub 2008 Jun 21.

DOI:10.1016/j.gene.2008.06.017
PMID:18640248
Abstract

Tbx2, a member of the T-box family of genes that encode developmentally important transcription factors, plays a critical role in development and has been linked to cancer. Here a 5'-flanking region of the human Tbx2 gene was cloned and characterized. While we identify a Sp1 element and a reverse CCAAT box to be essential for basal Tbx2 promoter activity, a physical interaction between Sp1 and NF-Y does not seem to be required for mediating their effect. Furthermore, our data reveal a downstream promoter element (DPE) in the Tbx2 promoter which significantly influences basal activity.

摘要

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