Merelli Ivan, Orro Alessandro, D'Agostino Daniele, Clematis Andrea
Institute for Biomedical Technologies, National Research Council, Segrate Milan, Italy.
Int J Bioinform Res Appl. 2008;4(3):221-39. doi: 10.1504/IJBRA.2008.019572.
In this paper we propose a parallel system for protein surface reconstruction based on techniques of computational geometry. The advantage of our modelling system is the production of both superficial and volumetric description of proteins. This is very important in protein analysis from the functional point of view, because many binding sites are buried inside the macromolecule. However the amount of data to process, both in the volume modelling and in extraction phase, may be huge, in proportion to the selected resolution of the output. For this reason the parallel implementation of the system represents a fundamental aspect in reducing the processing time.
在本文中，我们提出了一种基于计算几何技术的蛋白质表面重建并行系统。我们建模系统的优势在于能够生成蛋白质的表面和体积描述。从功能角度来看，这在蛋白质分析中非常重要，因为许多结合位点都埋藏在大分子内部。然而，无论是在体积建模还是提取阶段，要处理的数据量可能都非常大，这与输出的选定分辨率成正比。因此，系统的并行实现是减少处理时间的一个基本方面。
