Melo Hyder Aragão de, Barreto-Filho José Augusto S, Prado Roberto César P do, Cipolotti Rosana
Department of Medicine, University Hospital, Federal University of Sergipe, Aracaju, SE, Brazil.
Arq Neuropsiquiatr. 2008 Jun;66(2B):360-4. doi: 10.1590/s0004-282x2008000300015.
Environmental factors interfere on sickle cell anaemia (SCA). Transcanial Doppler (TCD) is important to evaluate cerebrovascular disease.
To evaluate brain haemodynamic profile of children with SCA in Sergipe.
Cross sectional study (group1: SCA patients aged 3-18; group2: age and sex matched healthy individuals). Baseline brain flow was evaluated.
Group1=34 patients; group 2=81 controls. SCA patients had mean velocity (MV)=125.69 cm/s+/-23.40; pulsatility index (PI)=0.66+/-0.10; middle cerebral artery ratio (MCAr)=14.53+/-15.23; right anterior cerebral artery/right middle cerebral artery=0.77+/-0.20; left anterior cerebral artery/left middle cerebral artery=0.78+/-0.20. Controls had MV=79.44+/-15.54; PI=0.82+/-0.11; MCAr=13.19+/-13.77; right anterior cerebral artery/right middle cerebral artery=0.80+/-0.16; left anterior cerebral artery/left middle cerebral artery=0.84+/-0.18. MV and PI differences were statistically significant between groups. MV was related to age but not to gender.
MV evaluation using TCD was similar to international standards and possible to be used in our setting.
环境因素会干扰镰状细胞贫血（SCA）。经颅多普勒（TCD）对于评估脑血管疾病很重要。
评估塞尔希培州SCA患儿的脑血流动力学特征。
横断面研究（第1组：3至18岁的SCA患者；第2组：年龄和性别匹配的健康个体）。评估基线脑血流。
第1组=34例患者；第2组=81例对照。SCA患者的平均流速（MV）=125.69厘米/秒±23.40；搏动指数（PI）=0.66±0.10；大脑中动脉比率（MCAr）=14.53±15.23；右大脑前动脉/右大脑中动脉=0.77±0.20；左大脑前动脉/左大脑中动脉=0.78±0.20。对照组的MV=79.44±15.54；PI=0.82±0.11；MCAr=13.19±13.77；右大脑前动脉/右大脑中动脉=0.80±0.16；左大脑前动脉/左大脑中动脉=0.84±0.18。两组之间MV和PI差异具有统计学意义。MV与年龄有关，但与性别无关。
使用TCD评估MV与国际标准相似，且有可能在我们的研究环境中使用。
