Bottai T, Levy C, Lancon C, Azorin J M, Grignon S, Valli M, Jadot G, Tissot R
Service de Pharmacologie Clinique et de Psychiatrie Biologique, Groupe Hospitalier de la Timone, Marseille.
Encephale. 1991 May-Jun;17(3):203-11.
Based on the hypocatecholaminergic hypothesis in the depressive syndromes, this survey on 30 depressed patients compared to 21 control patients, attempts to state exactly the potential interactions between the noradrenergic system and the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-thyroid neuroendocrine axis. The biological indices used during this survey are: total plasmatic MHPG, the basic plasmatic cortisol, the thyroid hormones T3, T4, free T4, and the TSH. The results of this survey reveal a significative increase of the basic plasmatic cortisol among the depressed patients, including dysthymics, a decrease of the plasmatic MHPG during major depressions, and a significant fall of the total T3 among depressed men, as well as some correlations between the different axes, the interpretation of which remains "ticklish".
基于抑郁综合征中的低儿茶酚胺能假说，这项针对30名抑郁症患者与21名对照患者的调查，试图确切阐述去甲肾上腺素能系统与下丘脑 - 垂体 - 肾上腺以及下丘脑 - 垂体 - 甲状腺神经内分泌轴之间的潜在相互作用。本次调查中使用的生物学指标包括：血浆总MHPG、基础血浆皮质醇、甲状腺激素T3、T4、游离T4以及促甲状腺激素。这项调查结果显示，在包括心境恶劣障碍患者在内的抑郁症患者中，基础血浆皮质醇显著升高；在重度抑郁发作期间血浆MHPG降低；在男性抑郁症患者中总T3显著下降；并且不同轴之间存在一些相关性，但其解读仍“棘手”。
