Gao Ai-bin, Xiao Qian, Li Long-ying, Gao Yuan, Zhang Hai-na, Miao Jing
Department of Gerontology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2008 Feb;42(2):107-10.
To investigate the association between non alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS).
A cross-sectional multiple-stage stratified survey was performed. A total of 2190 civil servants of Chongqing city were invited to participate in the survey covering physical examination, serum biochemistry-profile and ultrasonographic examination of liver.
Of 2176 valid questionnaires, altogether 455 cases were diagnosed as NAFLD and 231 individuals were diagnosed as MS. The prevalence of obesity, hyperglycemia, blood lipid disturbance, primary hypertension, NAFLD and MS was 38.3%, 5.5%, 31.7%, 29.9%, 20.9% and 10.6% respectively, which was increased along with aging (chi2 = 31.775, P = 0.000; chi2 = 25.985, P = 0.000; chi2 = 44.818, P = 0.000; chi2 =149.802, P = 0.000; chi2 = 61.302, P = 0.000; chi2 = 43.508, P = 0.000 a partly). The prevalence of obesity, hyperglycemia, dyslipidemia, primary hypertension, metabolic syndrome was significantly higher than those in control group (chi2 = 384.554, P = 0.000; chi2 = 25.597, P = 0.000; chi2 = 370.849, P = 0.000; chi2 = 40.252, P = 0.000; chi2 = 215.077, P = 0.000 separately), and the level of body mass index (BMI), fasting plasma glucose (FPG), triglyceride (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) in NAFLD group was remarkably higher than those in control group (t = 26.308, P = 0.000; t = 6.055, P = 0.000; t = 15.980, P = 0.000; t = 10.550, P = 0.000; t = 13.628, P = 0.000 respectively), while the level of high-density lipoprotein cholesterol (HDL-C) was on the opposite (t = 20.067, P = 0.000). Compared with the control group, odds risk for NAFLD was 22.82 folds (95% CI: 12.64-41.19) in obesity, 20.97 folds (95% CI: 11.21-39.24) in hyperglycemia, 24.40 folds (95% CI: 13.51-44.07) in dyslipidemia, 15.73 folds (95% CI: 8.66-28.60) in primary hypertension, while the risk for NAFLD was the highest in MS (OR = 31.06, 95% CI: 17.12-56.35). There were simple or multiple metabolic disorders in 455 individuals diagnosed as NAFLD, and 21 case (4.6%) with obesity, hyperglycemia, dyslipidemia and primary hypertension.
NAFLD is closely related with MS, which may be considered as a feature of MS.
探讨非酒精性脂肪性肝病（NAFLD）与代谢综合征（MS）之间的关联。
进行一项横断面多阶段分层调查。共邀请重庆市2190名公务员参与调查，内容包括体格检查、血清生化指标检测及肝脏超声检查。
在2176份有效问卷中，共455例被诊断为NAFLD，231例被诊断为MS。肥胖、高血糖、血脂紊乱、原发性高血压、NAFLD和MS的患病率分别为38.3%、5.5%、31.7%、29.9%、20.9%和10.6%，且均随年龄增长而升高（χ² = 31.775，P = 0.000；χ² = 25.985，P = 0.000；χ² = 44.818，P = 0.000；χ² = 149.802，P = 0.000；χ² = 61.302，P = 0.000；χ² = 43.508，P = 0.000部分）。肥胖、高血糖、血脂异常、原发性高血压、代谢综合征的患病率显著高于对照组（χ²分别为384.554，P = 0.000；χ² = 25.597，P = 0.000；χ² = 370.849，P = 0.000；χ² = 40.252，P = 0.000；χ² = 215.077，P = 0.000），NAFLD组的体重指数（BMI）、空腹血糖（FPG）、甘油三酯（TG）、收缩压（SBP）、舒张压（DBP）水平显著高于对照组（t分别为26.308，P = 0.000；t = 6.055，P = 0.000；t = 15.980，P = 0.000；t = 10.550，P = 0.000；t = 13.628，P = 0.000），而高密度脂蛋白胆固醇（HDL-C）水平则相反（t = 20.067，P = 0.000）。与对照组相比，肥胖者患NAFLD的比值风险为22.82倍（95%可信区间：12.64 - 41.19），高血糖者为20.97倍（95%可信区间：11.21 - 39.24），血脂异常者为24.40倍（95%可信区间：13.51 - 44.07），原发性高血压者为15.73倍（95%可信区间：8.66 - 28.60），而MS患者患NAFLD的风险最高（OR = 31.06，95%可信区间：17.12 - 56.35）。在455例被诊断为NAFLD的个体中存在单纯或多种代谢紊乱，21例（4.6%）同时患有肥胖、高血糖、血脂异常和原发性高血压。
NAFLD与MS密切相关，可将其视为MS的一个特征。
