通过一锅法铃木-宫浦偶联/羟醛缩合级联反应全合成马兜铃内酰胺
Total synthesis of aristolactams via a one-pot suzuki-miyaura coupling/aldol condensation cascade reaction.
作者信息
Kim Joa Kyum, Kim Young Ha, Nam Ho Tae, Kim Bum Tae, Heo Jung-Nyoung
机构信息
Center for Medicinal Chemistry, Korea Research Institute of Chemical Technology, 100 Jang-dong, Daejeon 305-600, Korea.
出版信息
Org Lett. 2008 Aug 21;10(16):3543-6. doi: 10.1021/ol801291k. Epub 2008 Jul 19.
A direct one-pot synthesis of phenanthrene lactams, which employs a Suzuki-Miyaura coupling/aldol condensation cascade reaction of isoindolin-1-one with 2-formylphenylboronic acid, has been developed. The approach is used to efficiently produce a number of natural aristolactams, such as aristolactam BII (cepharanone B), aristolactam BIII, aristolactam FI (piperolactam A), N-methyl piperolactam A, and sauristolactam.
已开发出一种菲内酰胺的直接一锅法合成方法，该方法采用异吲哚啉-1-酮与2-甲酰基苯硼酸的铃木-宫浦偶联/羟醛缩合级联反应。该方法用于高效生产多种天然马兜铃内酰胺，如马兜铃内酰胺BII（头花千金藤酮B）、马兜铃内酰胺BIII、马兜铃内酰胺FI（胡椒内酰胺A）、N-甲基胡椒内酰胺A和细辛马兜铃内酰胺。
Zotero 插件