Kim Young Ha, Lee Hyuk, Kim Yeong Joon, Kim Bum Tae, Heo Jung-Nyoung
Department of Chemistry, Chungnam National University, 220 Gung-dong, Daejeon 305-764, Korea.
J Org Chem. 2008 Jan 18;73(2):495-501. doi: 10.1021/jo702001n. Epub 2007 Dec 23.
We have developed an efficient cascade reaction, a Suzuki-Miyaura coupling followed by an aldol condensation, for the construction of phenanthrene derivatives using microwave irradiation. For example, the reaction of methyl 2-bromophenylacetamide with 2-formylphenylboronic acid in the presence of a palladium catalyst and a base provided a biaryl intermediate, which underwent in situ cyclization to afford the corresponding phenanthrene in high yield.
我们开发了一种高效的级联反应，即先进行铃木-宫浦偶联反应，然后进行羟醛缩合反应，用于在微波辐射下构建菲衍生物。例如，2-溴苯基乙酰胺与2-甲酰基苯硼酸在钯催化剂和碱的存在下反应，得到一个联芳基中间体，该中间体原位环化，以高产率得到相应的菲。
