使用新型无痕连接策略进行可溶性聚合物负载的5-亚芳基噻唑烷酮和嘧啶酮的合成。

Soluble polymer-supported synthesis of 5-arylidene thiazolidinones and pyrimidinones using a novel traceless linker strategy.

作者信息

Liu Zhang, Huang Yue, Zhang Wei, Ma Lanping, Li Jingya, Wang Xin, Li Jia, Shen Jingkang

机构信息

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, PR China.

出版信息

J Comb Chem. 2008 Sep-Oct;10(5):632-6. doi: 10.1021/cc800054e. Epub 2008 Jul 22.

DOI:10.1021/cc800054e

PMID:18642887

Abstract

An efficient method for the soluble polymer-supported synthesis of 5-arylidene thiazolidinones and pyrimidinones using aniline as a traceless linker was described. Aldehyde substrates were attached to the polyethylene glycol (PEG)-bound aniline via an imine linkage, and after the subsequent PEG-promoted Suzuki coupling reaction for the diversification, Knoevenagel condensation was readily employed as the cleavage strategy.

摘要

描述了一种使用苯胺作为无痕连接基，可溶聚合物负载合成5-亚芳基噻唑烷酮和嘧啶酮的有效方法。醛底物通过亚胺键连接到聚乙二醇（PEG）连接的苯胺上，在随后用于多样化的PEG促进的铃木偶联反应之后，克诺文格尔缩合很容易被用作裂解策略。