通过胃泌素免疫中和抑制大鼠进食刺激的胃酸分泌。

Inhibition of meal-stimulated gastric acid secretion by gastrin immunoneutralization in rats.

作者信息

Van de Brug F J, Jansen J B, Kuijpers R J, Lamers C B

机构信息

Department of Gastroenterology and Hepatology, University Hospital Leiden, The Netherlands.

出版信息

Eur J Pharmacol. 1991 Jun 6;198(2-3):197-201. doi: 10.1016/0014-2999(91)90621-v.

DOI:10.1016/0014-2999(91)90621-v

PMID:1864306

Abstract

Gastrin 17-I was infused into conscious rats equipped with jugular and portal vein catheters and with a pyloric gastric drainage tube to achieve serum concentrations slightly higher than those found during intragastrically instilled peptone solutions. I.v. injected rabbit gastrin antiserum abolished gastrin 17-I-stimulated gastric acid secretion in these animals. Gastrin immunoneutralization reduced peptone-stimulated gastric acid secretion by approximately 37% during the entire 30-min period of stimulation. Peptone-stimulated gastric acid secretion was only significantly (P less than 0.05) inhibited in the third 10-min period, but not in the first or second 10-min periods of stimulation. This study demonstrates that the late but not the initial period of peptone-stimulated gastric acid secretion is regulated by circulating gastrin in rats.

摘要

将胃泌素17-I注入装有颈静脉和门静脉导管以及幽门胃引流管的清醒大鼠体内，以使血清浓度略高于胃内滴注蛋白胨溶液时的浓度。静脉注射兔胃泌素抗血清可消除这些动物中胃泌素17-I刺激的胃酸分泌。在整个30分钟的刺激期内，胃泌素免疫中和使蛋白胨刺激的胃酸分泌减少了约37%。蛋白胨刺激的胃酸分泌仅在刺激的第三个10分钟期间受到显著抑制（P<0.05），而在刺激的第一个或第二个10分钟期间未受到抑制。本研究表明，在大鼠中，蛋白胨刺激胃酸分泌的后期而非初期受循环胃泌素调节。