Halliday G M, McRitchie D A, Cartwright H, Pamphlett R, Hely M A, Morris J G
Prince of Wales Medical Research Institute, Randwick, Australia; Neuropathology Division, Department of Pathology, University of Sydney, Australia.
J Clin Neurosci. 1996 Jan;3(1):52-60. doi: 10.1016/s0967-5868(96)90083-1.
We have quantified midbrain cell loss in idiopathic Parkinson's disease (PD) compared with controls; six patients had PD with onset before 70 years, five patients had late onset PD (>70 years) and nine patients had diffuse Lewy body disease. The pattern of cell loss in these last two groups has not been previously described. No age associated neuronal loss was seen in controls. There was cell loss and reduced area of the pars compacta in all cases but no difference in the pattern of cell loss, which was predominantly ventral. The amount of cell loss in the dorsolateral cluster correlated with the duration of Parkinsonian symptoms, while greater cell loss in the dorsomedial cluster correlated with the presence of tremor and the absence of early dementia. These results suggest that the topography of midbrain pathology does not assist in differentiating these overlapping syndromes.
我们已对特发性帕金森病（PD）患者与对照组的中脑细胞损失进行了量化；6例患者为70岁之前发病的PD，5例患者为晚发性PD（>70岁），9例患者为弥漫性路易体病。后两组的细胞损失模式此前尚未见描述。对照组未见与年龄相关的神经元损失。所有病例均存在细胞损失且黑质致密部面积减小，但细胞损失模式无差异，主要为腹侧损失。背外侧簇的细胞损失量与帕金森症状持续时间相关，而背内侧簇中更大的细胞损失与震颤的存在及早期痴呆的缺失相关。这些结果表明，中脑病理学的局部解剖结构无助于区分这些重叠综合征。
