Tiveron Marie-Catherine, Cremer Harold
Developmental Biology Institute of Marseille-Luminy, CNRS/University Méditerranée, Campus de Luminy, Case 907, 13288 Marseille cedex 9, France.
Curr Opin Neurobiol. 2008 Jun;18(3):237-44. doi: 10.1016/j.conb.2008.06.004.
The chemokine CXCL12 (or SDF-1) and its receptor CXCR4 have originally been described as regulators of cell interactions in the immune system. However, over the past years it has become clear that this receptor/ligand pair is an important component of the machinery that controls cell migration in different regions of the developing nervous system. Here we will review some of these functions of the CXCL12/CXCR4 system, focusing on migration events in the cerebellum and the cortex. Furthermore, we will discuss these findings in light of the recently discovered second receptor for CXCL12, CXCR7, and the original functional properties of this molecule that have been described in zebrafish.
趋化因子CXCL12（或SDF-1）及其受体CXCR4最初被描述为免疫系统中细胞相互作用的调节因子。然而，在过去几年中，已经明确该受体/配体对是控制发育中神经系统不同区域细胞迁移机制的重要组成部分。在这里，我们将回顾CXCL12/CXCR4系统的一些功能，重点关注小脑和皮质中的迁移事件。此外，我们将根据最近发现的CXCL12的第二种受体CXCR7以及在斑马鱼中描述的该分子的原始功能特性来讨论这些发现。
