Kubachka Kevin M, Richardson Douglas D, Heitkemper Douglas T, Caruso Joseph A
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221, USA.
J Chromatogr A. 2008 Aug 22;1202(2):124-31. doi: 10.1016/j.chroma.2008.04.028. Epub 2008 Apr 20.
The following work presents the exploration of three chromatographic separations in combination with inductively coupled plasma mass spectrometry (ICP-MS) for the analysis of chemical warfare agent degradation products (CWADPs). The robust ionization of ICP is virtually matrix independent thus enabling the examination of sample matrices generally considered too complicated for analysis by electrospray ionization (ESI) or atmospheric pressure chemical ionization MS with little to no sample preparation. The analysis was focused on detecting CWADPs in food matrices, as they present possible vehicles for terrorist contamination. Due to the specific detection of (31)P by ICP-MS, resolution of analytes of interest from other P-containing interferences (H(3)PO(4)) was a crucial part of each separation. Up to 10 CWADPs were separated in the presence of H(3)PO(4) with detection limits in the low part per billion levels using the methods described. Additionally, one method was tailored to be compatible with both ICP-MS and ESI-MS making structural verification possible.
以下工作介绍了三种色谱分离方法与电感耦合等离子体质谱法（ICP-MS）相结合用于分析化学战剂降解产物（CWADPs）的研究。ICP的强大电离几乎与基质无关，因此能够对通常被认为过于复杂而无法通过电喷雾电离（ESI）或大气压化学电离质谱进行分析的样品基质进行检测，且几乎无需样品制备。该分析聚焦于检测食品基质中的CWADPs，因为它们可能是恐怖分子污染的载体。由于ICP-MS对（31）P的特异性检测，从其他含磷干扰物（H(3)PO(4)）中分离出感兴趣的分析物是每次分离的关键部分。使用所述方法，在存在H(3)PO(4)的情况下，可分离多达10种CWADPs，检测限低至十亿分之几。此外，有一种方法经过调整，可与ICP-MS和ESI-MS兼容，从而实现结构验证。
