阿托伐他汀与夫西地酸联用导致的横纹肌溶解症。

Rhabdomyolysis with atorvastatin and fusidic acid.

作者信息

O'Mahony C, Campbell V L, Al-Khayatt M S, Brull D J

机构信息

The Heart Hospital, 16-18 Westmoreland Street, London W1G 8PH, UK.

出版信息

Postgrad Med J. 2008 Jun;84(992):325-7. doi: 10.1136/pgmj.2007.064097.

DOI:10.1136/pgmj.2007.064097

PMID:18644925

Abstract

Rhabdomyolysis is a rare but life-threatening complication of statin therapy. A 74-year-old man, treated with atorvastatin, developed rhabdomyolysis after the co-administration of fusidic acid and flucloxacillin. The patient recovered with supportive treatment and subsequently tolerated reintroduction of atorvastatin. Pharmacokinetic interactions can cause raised plasma statin concentrations, which can precipitate rhabdomyolysis in the presence of certain predisposing biological factors.

摘要

横纹肌溶解症是他汀类药物治疗罕见但危及生命的并发症。一名74岁男性，接受阿托伐他汀治疗，在联用夫西地酸和氟氯西林后发生横纹肌溶解症。患者经支持治疗后康复，随后耐受了阿托伐他汀的重新使用。药代动力学相互作用可导致血浆他汀类药物浓度升高，在某些易感生物学因素存在的情况下，这可能促使横纹肌溶解症的发生。