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Rhabdomyolysis secondary to interaction of fusidic acid and simvastatin.
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Acute rhabdomyolysis after atorvastatin and fusidic acid therapy.阿托伐他汀与夫西地酸治疗后急性横纹肌溶解症
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辛伐他汀与夫西地酸相互作用所致横纹肌溶解症。

Rhabdomyolysis caused by an interaction of simvastatin and fusidic acid.

作者信息

Herring Roselle, Caldwell Gordon, Wade Stuart

机构信息

Worthing and Southlands NHS Trust, Endocrine and Diabetes, Worthing Hospital, Lyndhurst Road, West Sussex, BN11 2DH, UK.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.03.2009.1722. Epub 2009 Sep 20.

DOI:10.1136/bcr.03.2009.1722
PMID:21931583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3027476/
Abstract

A case of severe rhabdomyolysis caused by an interaction between fusidic acid and simvastatin is described. Fusidic acid significantly reduces the excretion of simvastatin resulting in increased plasma levels thereby increasing the side effect profile. Simvastatin treatment should be temporarily withheld during treatment with fusidic acid.

摘要

本文描述了一例因夫西地酸与辛伐他汀相互作用导致的严重横纹肌溶解症。夫西地酸显著减少辛伐他汀的排泄，导致血浆水平升高，从而增加副作用。在用夫西地酸治疗期间，应暂时停用辛伐他汀治疗。