Souki-Rincón Aida, Urdaneta Janet, Mengual Edgardo, Torres Diamira, Cano-Peñaloza Raquel, García-Camacho Doris, Bermúdez-Pírela Valmore, Sorell Luis, Cano-Ponce Climaco, Almarza Johan, Israili Zafar, Hernández-Hernandez Rafael, Velasco Manuel
Centro de Investigaciones Endocrino-Metabólicas Dr. Félix Gómez, Facultad de Medicina, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela.
Am J Ther. 2008 Jul-Aug;15(4):403-8. doi: 10.1097/MJT.0b013e31815fa7a6.
The aims of this study were to determine Lipoprotein (a) [Lp(a)] concentrations in a sample of subjects from Maracaibo, Venezuela, and to determine the relationship of family risk factors for cardiovascular disease and their Lp(a) levels. Two hundred twenty-seven healthy individuals between 5 and 19 years of age of both genders and multiethnic origins were selected. A complete background clinical chart and laboratory test was conducted for each patient to discard cardiovascular diseases and confirm their healthy state. The Lp(a) concentration was determined using the double antibody enzyme-linked immunosorbent assay method. For inferential statistical analysis, one-factor analysis of variance tests and Student t test for independent observations were used according to each case, considered significant when P value was <0.05. No significant differences were observed when evaluating Lp(a) levels according to gender in all ages. Males showed no significant difference in Lp(a) levels between groups, but, in females, a significantly lower level (P < 0.03) in the group 5 to 9 years of age was found. When considering only age, significantly lower levels were observed (P < 0.03) in the 5- to 9-year-old group. When studying family risk factors of cardiovascular diseases, it was found that the group with family risk factors had a significantly higher Lp(a) concentration (P < 0.01) than those without family risk factors, observing that those who had four or more factors exhibited a significantly higher concentration than those with two to three risk factors (30.6 +/- 4.5 mg/dL versus 18.5 +/- 12.2 mg/dL, P < 0.009) and than those with one risk factor (30.6 +/- 4.5 mg/dL versus 21.6 +/- 1.4 mg/dL, P < 0.03). These results emphasize the clusters of family risk factors of cardiovascular disease with higher Lp(a) levels and also indicate that the evaluation of its concentration should be taken as an independent risk factor of atherosclerosis for the population in developmental ages.
本研究的目的是测定委内瑞拉马拉开波市一组受试者的脂蛋白(a)[Lp(a)]浓度，并确定心血管疾病家族风险因素与他们的Lp(a)水平之间的关系。选取了227名年龄在5至19岁之间、具有多种族背景的健康个体，男女不限。为每位患者进行了完整的临床病史记录和实验室检查，以排除心血管疾病并确认其健康状态。采用双抗体酶联免疫吸附测定法测定Lp(a)浓度。对于推断性统计分析，根据具体情况使用单因素方差分析检验和独立观察的学生t检验，当P值<0.05时认为具有显著性。在所有年龄段中，根据性别评估Lp(a)水平时未观察到显著差异。男性组间Lp(a)水平无显著差异，但在女性中，5至9岁组的Lp(a)水平显著较低(P<0.03)。仅考虑年龄时，5至9岁组的Lp(a)水平显著较低(P<0.03)。在研究心血管疾病的家族风险因素时，发现有家族风险因素的组Lp(a)浓度显著高于无家族风险因素的组(P<0.01)，观察到有四个或更多风险因素的个体其Lp(a)浓度显著高于有两个至三个风险因素的个体(30.6±4.5mg/dL对18.5±12.2mg/dL，P<0.009)以及有一个风险因素的个体(30.6±4.5mg/dL对21.6±l.4mg/dL，P<0.03)。这些结果强调了心血管疾病家族风险因素与较高Lp(a)水平之间的关联，也表明应将其浓度评估作为发育年龄段人群动脉粥样硬化的一个独立风险因素。
