人绒毛膜促性腺激素给药当天血清孕酮水平高是否会影响卵胞浆内单精子注射和胚胎移植后的妊娠率？
Does high serum progesterone level on the day of human chorionic gonadotropin administration affect pregnancy rate after intracytoplasmic sperm injection and embryo transfer?
作者信息
Azem Foad, Tal Guy, Lessing Joseph B, Malcov Mira, Ben-Yosef Dalit, Almog Beni, Amit Ami
机构信息
The Sara Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Gynecol Endocrinol. 2008 Jul;24(7):368-72. doi: 10.1080/09513590802196353.
OBJECTIVE
The present study was conducted to evaluate the effect of serum progesterone (P) levels on the day of human chorionic gonadotropin (hCG) administration on embryo quality and pregnancy rate in intracytoplasmic sperm injection (ICSI) cycles.
DESIGN AND SETTING
This was a retrospective analysis conducted in the in vitro fertilization (IVF) unit of a tertiary hospital.
PATIENTS
Two hundred and one patients who underwent a total of 280 IVF treatment cycles allocated to ICSI during routine IVF/embryo transfer treatment. Results. In cycles with elevated serum P, higher estradiol levels were noted (1915 pg/ml vs. 1256 pg/ml; p<0.05), more oocytes were retrieved and manipulated, and more embryos were available for transfer. Embryo grading was comparable between the two groups. The average age was lower in the group with elevated P; but the pregnancy rate was significantly lower (16.4% vs. 27.6%, p = 0.03).
CONCLUSIONS
Our data demonstrate no deleterious effect of elevated P on embryo quality. However, high serum P adversely affects implantation and pregnancy rates.
目的
本研究旨在评估人绒毛膜促性腺激素（hCG）注射日血清孕酮（P）水平对卵胞浆内单精子注射（ICSI）周期中胚胎质量和妊娠率的影响。
设计与背景
这是一项在一家三级医院体外受精（IVF）单元进行的回顾性分析。
患者
201例患者在常规IVF/胚胎移植治疗期间共进行了280个分配至ICSI的IVF治疗周期。结果。在血清P升高的周期中，观察到雌二醇水平更高（1915 pg/ml对1256 pg/ml；p<0.05），获取和操作的卵母细胞更多，可供移植的胚胎更多。两组之间胚胎分级相当。P升高组的平均年龄较低；但妊娠率显著较低（16.4%对27.6%，p = 0.03）。
结论
我们的数据表明P升高对胚胎质量无有害影响。然而，高血清P会对着床和妊娠率产生不利影响。
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