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IDPH-791的临床前毒性:一种新型中枢性肌肉松弛剂在大鼠中的研究

Pre-clinical toxicity of IDPH-791: a new centrally acting muscle relaxant in rats.

作者信息

Varma R K, Rajasekaran M, Junnarkar A Y, Singh P P, Krishnamurthy A, Thapar G S, Marathe M R

机构信息

Biology Division, IDPL Research Centre, Hyderabad, India.

出版信息

Indian J Exp Biol. 1991 Jan;29(1):91-3.

PMID:1864628
Abstract

IDPH-791, a novel centrally acting muscle relaxant, in doses up to 500 mg/kg (po) for 14 days did not result in any appreciable adverse effect on body weight gain, food or water consumption including biochemical and haematologica parameters in rats. Variations observed in the biochemistry and haematology were either comparable to controls or were within normal limits.

摘要

新型中枢性肌肉松弛剂IDPH - 791,以高达500毫克/千克的剂量口服给药14天,对大鼠的体重增加、食物或水的摄入量均未产生任何明显的不良影响,包括生化和血液学参数。在生化和血液学方面观察到的变化与对照组相当或在正常范围内。

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