Pan S C, List B
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr, Germany.
Ernst Schering Found Symp Proc. 2007(2):1-43.
Organocatalysis, catalysis with low-molecular weight catalysts in which a metal is not part of the catalytic principle or the reaction substrate, can be as efficient and selective as metal- or biocatalysis. Important discoveries in this area include novel Lewis base-catalyzed enantioselective processes and, more recently, simple Brønsted acid organocatalysts that rival the efficiency of traditional metal-based asymmetric Lewis acid-catalysts. Contributions to organocatalysis from our laboratories include several new and broadly useful concepts such as enamine catalysis and asymmetric counteranion-directed catalysis. Our laboratory has discovered the proline-catalyzed direct asymmetric intermolecular aldol reaction and introduced several other organocatalytic reactions.
有机催化是指使用低分子量催化剂进行的催化反应，其中金属不是催化原理或反应底物的一部分，其效率和选择性可与金属催化或生物催化相媲美。该领域的重要发现包括新型路易斯碱催化的对映选择性反应，以及最近出现的简单布朗斯特酸有机催化剂，其效率可与传统的基于金属的不对称路易斯酸催化剂相匹敌。我们实验室对有机催化的贡献包括几个新的且广泛有用的概念，如烯胺催化和不对称抗衡离子导向催化。我们实验室发现了脯氨酸催化的直接不对称分子间羟醛缩合反应，并引入了其他几种有机催化反应。
