Xiao Xincai, Lai Xiaohua, Luo Xiaolin, Su Yixiang
Guangzhou Center for Disease Control and Prevention, Guangzhou 510080, China.
Wei Sheng Yan Jiu. 2008 May;37(3):322-4.
To evaluate the effect of body fat composition and distribution on plasma lipid profile and oxidative stress in middle-aged women.
181 healthy Chinese women (age ranged from 35 to 50 years) were recruited. Their body fat mass and distribution were measured by dual-energy x-ray absorptiometry (DEXA). The oxidative status were evaluated by determination of serum levels of tumor necrosis factor-alpha (TNF-alpha), Glutathione peroxidase (GR) and Superoxide dismutase (SOD) and the plasma lipids, including total cholesterol (TC) and Triglycerides (TG) were also measured.
(1) Plasma TG and TC levels and serum TNF-alpha levels were significantly higher in overweight and obese women, while serum SOD and GR activity were significantly in these 2 groups, compared to normal-weight women. (2) Serum SOD and GR activity decreased, and TNF-alpha level increased with body mass index (BMI) and abdominal fat mass, as shown by linear correlation analysis. No correlation was found between serum oxidative indices, lipids and total body and subcutaneous fat. (3) The percentage of abdominal fat mass had positive correlations with the SOD and GR, and negative correlations with TNF-alpha. Whereas the percentage of subcutaneous fat mass did not have correction relationship with TNF-alpha, SOD, GR, but had negative correlation with TG and TC. (4) By the partial correlations analysis, abdominal fat mass were found to be negatively correlated with serum SOD and GR, and positively correlated with serum TNF-alpha.
Abdominal fat accumulation could be the marker of the oxidative stress and would elevate serum triglycerides and total cholesterols.
评估身体脂肪组成和分布对中年女性血浆脂质谱和氧化应激的影响。
招募了181名健康的中国女性（年龄在35至50岁之间）。通过双能X线吸收法（DEXA）测量她们的体脂肪量和分布。通过测定血清肿瘤坏死因子-α（TNF-α）、谷胱甘肽过氧化物酶（GR）和超氧化物歧化酶（SOD）水平来评估氧化状态，同时还测量了血浆脂质，包括总胆固醇（TC）和甘油三酯（TG）。
（1）与体重正常的女性相比，超重和肥胖女性的血浆TG和TC水平以及血清TNF-α水平显著更高，而这两组中的血清SOD和GR活性显著更低。（2）线性相关分析显示，血清SOD和GR活性降低，TNF-α水平随体重指数（BMI）和腹部脂肪量增加。血清氧化指标、脂质与全身及皮下脂肪之间未发现相关性。（3）腹部脂肪量百分比与SOD和GR呈正相关，与TNF-α呈负相关。而皮下脂肪量百分比与TNF-α、SOD、GR无校正关系，但与TG和TC呈负相关。（4）通过偏相关分析发现，腹部脂肪量与血清SOD和GR呈负相关，与血清TNF-α呈正相关。
腹部脂肪堆积可能是氧化应激的标志物，并会升高血清甘油三酯和总胆固醇。
