Cui Weimin, Yang Weidong, Liu Jiesheng
Department of Biotechnology, Jinan University, Guangzhou 510632, China.
Wei Sheng Yan Jiu. 2008 May;37(3):377-80.
Paralytic shellfish poisoning (PSP) toxins could be neuromuscular paralysis agents, which could blocke the voltage-gated sodium channels, and then could cause holdback in nervous system transmission. Some bivalves could be tolerant of PSP toxins. The resistance mechanisms might be related to metabolism, biotransformation and the mutation of voltage-gated sodium channels, etc., in which the mutation of sodium channels might be the most important molecular mechanism of the resistance mechanism of bivalves.
麻痹性贝类中毒（PSP）毒素可能是神经肌肉麻痹剂，它可阻断电压门控钠通道，进而导致神经系统传递受阻。一些双壳贝类能够耐受PSP毒素。其抗性机制可能与代谢、生物转化以及电压门控钠通道的突变等有关，其中钠通道的突变可能是双壳贝类抗性机制中最重要的分子机制。
