Satoh Yasuo, Ide Yasuo, Sugano Takayuki, Koda Kenichiro, Momose Yasunori, Tagami Megumi
Department of Anesthesiology, Toho University, Sakura Medical Center, Sakura, Chiba 285-8741, Japan.
Nihon Arukoru Yakubutsu Igakkai Zasshi. 2008 Jun;43(3):188-93.
Intravenous injection of acetaldehyde produced hypotensive actions in pentobarbital-anaesthetised whole rats, but hypertensive actions in pithed rats. The hypotensive effects of acetaldehyde in whole rats were abolished by pre-treatment with yohimbine. In pithed rats, the hypertensive effects of acetaldehyde were significantly attenuated by prazosin and phentolamine, and in rats that had been pre-treated with reserpine. Our results suggest that the hypertensive actions of acetaldehyde in pithed rats are due to the release of catecholamines, which subsequently leads to vasoconstriction. In whole rats the hypotensive actions of acetaldehyde may be due to alpha2-adrenoceptor stimulation in the central nervous or peripheral system.
静脉注射乙醛在戊巴比妥麻醉的整体大鼠中产生降压作用，但在去脑大鼠中产生升压作用。用育亨宾预处理可消除乙醛在整体大鼠中的降压作用。在去脑大鼠中，哌唑嗪和酚妥拉明以及用利血平预处理的大鼠可显著减弱乙醛的升压作用。我们的结果表明，乙醛在去脑大鼠中的升压作用是由于儿茶酚胺的释放，随后导致血管收缩。在整体大鼠中，乙醛的降压作用可能是由于中枢神经系统或外周系统中的α2-肾上腺素能受体受到刺激。
