Matsumori A, Yamada T, Tamaki N, Watanabe Y, Yonekura Y, Endo K, Konishi J, Yoshida A, Kawai C
Department of Internal Medicine, Faculty of Medicine; Kyoto University, Japan.
Int J Cardiol. 1991 Jul;32(1):75-81. doi: 10.1016/0167-5273(91)90046-r.
The prognostic significance of myocardial uptake of indium-111 antimyosin was evaluated in 15 patients with idiopathic cardiomyopathy: 10 patients with dilated cardiomyopathy and 5 patients with hypertrophic cardiomyopathy. Seven of the 10 patients with dilated cardiomyopathy showed positive images; three of these 7 patients with strongly positive scans died within 3 months after scintigraphic examination. Four of the 5 patients with hypertrophic cardiomyopathy showed positive images; two of these patients with dilated left ventricle had prominent positive scans and higher heart to lung ratio. One of these two patients died 12 months after antimyosin scan. The heart to lung ratio of antimyosin uptake in total patients was correlated with left ventricular end-diastolic dimension (r = 0.51, P less than 0.05), end-systolic dimension (r = 0.57, P less than 0.05) and ejection fraction (r = -0.60, P less than 0.05) measured by echocardiography. Although the number of patients is small and the study is preliminary, indium-111 antimyosin antibody imaging could be of value in establishing prognosis of patients with dilated and hypertrophic cardiomyopathy, in selecting patients for cardiac transplantation, and in evaluating the effects of therapeutic interventions.
对15例特发性心肌病患者（10例扩张型心肌病患者和5例肥厚型心肌病患者）进行了铟111抗肌凝蛋白心肌摄取的预后意义评估。10例扩张型心肌病患者中有7例显示阳性图像；这7例扫描结果强阳性的患者中，有3例在闪烁扫描检查后3个月内死亡。5例肥厚型心肌病患者中有4例显示阳性图像；这4例左心室扩张的患者扫描结果呈显著阳性，且心/肺比值更高。这2例患者中有1例在抗肌凝蛋白扫描后12个月死亡。通过超声心动图测量，所有患者抗肌凝蛋白摄取的心/肺比值与左心室舒张末期内径（r = 0.51，P < 0.05）、收缩末期内径（r = 0.57，P < 0.05）及射血分数（r = -0.60，P < 0.05）相关。尽管患者数量较少且研究尚属初步，但铟111抗肌凝蛋白抗体显像在确定扩张型和肥厚型心肌病患者的预后、选择心脏移植患者以及评估治疗干预效果方面可能具有价值。
