一种基于四聚体雌酮的大环化合物的直接合成方法。

A straightforward synthesis of tetrameric estrone-based macrocycles.

作者信息

Ramírez-López Pedro, de la Torre María C, Montenegro Hector E, Asenjo María, Sierra Miguel A

机构信息

Instituto de Química Orgánica, Consejo Superior de Investigaciones Científicas (CSIC), Juan de la Cierva 3, 28006-Madrid, Spain.

出版信息

Org Lett. 2008 Aug 21;10(16):3555-8. doi: 10.1021/ol801313g. Epub 2008 Jul 23.

DOI:10.1021/ol801313g

PMID:18646766

Abstract

A straightforward approach to macrocycles having four estrone-derived nuclei by the sequential Cu-catalyzed Huisgen azide-alkyne cycloaddition-Glaser-Eglington Cu homocoupling has been developed. Due to its efficiency and simplicity, this sequence is useful for application to different natural product scaffolds.

摘要

通过连续的铜催化胡伊斯根叠氮化物-炔烃环加成-格拉泽-埃格林顿铜均偶联反应，已经开发出一种合成具有四个雌酮衍生核的大环化合物的直接方法。由于其高效性和简便性，该反应序列可用于不同天然产物骨架的合成。