（-）-MITH催化二甲基锌对α-酮酯的不对称加成反应。
Asymmetric addition of dimethylzinc to alpha-ketoesters catalyzed by (-)-MITH.
作者信息
Wu Hsyueh-Liang, Wu Ping-Yu, Shen Ying-Ying, Uang Biing-Jiun
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China.
出版信息
J Org Chem. 2008 Aug 15;73(16):6445-7. doi: 10.1021/jo801034q. Epub 2008 Jul 23.
PMID:18646857
Abstract
This investigation describes the catalytic asymmetric addition of dimethylzinc to alpha-ketoesters in the presence of (-)-MITH ( 5) and triethyl borate as an additive to give the corresponding chiral alpha-hydroxy esters with good yields and high enantioselectivities.
摘要
本研究描述了在（-）-MITH（5）和硼酸三乙酯作为添加剂存在的条件下，二甲基锌对α-酮酯的催化不对称加成反应，以良好的产率和高对映选择性得到相应的手性α-羟基酯。
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