de Peretti E, Forest M G
J Clin Endocrinol Metab. 1976 Nov;43(5):982-91. doi: 10.1210/jcem-43-5-982.
A specific and sensitive radioimmunoassay for measuring unconjugated plasma dehydroepiandrosterone (DHA) has been developed and the results expressed in ng/100 ml. Mean values +/-1 SD were in mixed cord blood 593.3 +/- 186.5 in 21 females and 712.7 +/- 190.9 in 18 males. During the first day of life the peripheral plasma concentration of DHA was 917.6 +/- 317.8 in 22 female and 922.65 +/- 290 in 17 male neonates. During the first month of age, DHA levels decreased significantly and then more progressively throughout the first year of life. Mean levels observed between the first and 6th month of life were 147.1 +/- 53.6 in 15 girls and 151.6 +/- 62.7 in 28 boys. Between 6 and 12 months of age mean DHA levels were 90.9 +/- 43.3 and 68.14 +/- 30.9 in 11 girls and 24 boys, respectively. In 250 normal children, plasma DHA levels were very low between 1 to 6 years of age, but rising progressively thereafter without any sex difference long before any clinical sign of puberty. A circadian rhythm parallel to that of cortisol was observed as early as 5 years of age. Acute and chronic stimulation of ACTH confirmed the adrenal origin of DHA, while the results of hCG stimulation test and fluoxymesterone suppression test assessed the testicular participation to the DHA production.
已开发出一种用于测量未结合血浆脱氢表雄酮（DHA）的特异性和灵敏性放射免疫测定法，结果以纳克/100毫升表示。21名女性混合脐血中的平均值±1标准差为593.3±186.5，18名男性为712.7±190.9。在出生第一天，22名女新生儿和17名男新生儿外周血浆DHA浓度分别为917.6±317.8和922.65±290。在出生后的第一个月，DHA水平显著下降，然后在生命的第一年中更逐渐下降。在出生后第一个月至第六个月期间观察到的平均水平，15名女孩为147.1±53.6，28名男孩为151.6±62.7。在6至12个月龄之间，11名女孩和24名男孩的平均DHA水平分别为90.9±43.3和68.14±30.9。在250名正常儿童中，1至6岁之间血浆DHA水平非常低，但此后逐渐上升，在青春期任何临床迹象出现之前很久就没有任何性别差异。早在5岁时就观察到与皮质醇平行的昼夜节律。促肾上腺皮质激素（ACTH）的急性和慢性刺激证实了DHA的肾上腺来源，而人绒毛膜促性腺激素（hCG）刺激试验和氟甲睾酮抑制试验的结果评估了睾丸对DHA产生的参与情况。
