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Gatifloxacin-induced severe hyperglycaemia and ketoacidosis in a non-diabetic renal transplant recipient.

作者信息

Khaira Ambar, Gupta Ankur, Tandon Nikhil, Agarwal Sanjay K

机构信息

Department of Nephrology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.

出版信息

Clin Exp Nephrol. 2009 Feb;13(1):89-91. doi: 10.1007/s10157-008-0072-3. Epub 2008 Jul 17.

DOI:10.1007/s10157-008-0072-3
PMID:18648734
Abstract

Gatifloxacin has been reported to cause dysglycaemia, especially in the elderly and in diabetics. In this communication, we describe a case of a non-diabetic renal transplant recipient who came to us in a state of diabetic ketoacidosis following the use of gatifloxacin for a urinary tract infection.

摘要

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本文引用的文献

1
Advancing age and renal impairment as important predisposing factors of gatifloxacin-induced hyperglycemia in non-diabetes patients.高龄和肾功能损害是加替沙星致非糖尿病患者高血糖的重要易感因素。
J Med Assoc Thai. 2007 Mar;90(3):569-73.
2
Gatifloxacin-induced hyperglycemia: a case report and summary of the current literature.加替沙星引起的高血糖症：一例病例报告及当前文献综述
Clin Ther. 2006 Nov;28(11):1857-66. doi: 10.1016/j.clinthera.2006.11.014.
3
People with diabetes should avoid antibiotic gatifloxacin.糖尿病患者应避免使用抗生素加替沙星。
CMAJ. 2006 Apr 11;174(8):1089-90. doi: 10.1503/cmaj.060356. Epub 2006 Mar 22.
4
Outpatient gatifloxacin therapy and dysglycemia in older adults.门诊加替沙星治疗与老年人血糖异常
N Engl J Med. 2006 Mar 30;354(13):1352-61. doi: 10.1056/NEJMoa055191. Epub 2006 Mar 1.
5
Effects of gatifloxacin on serum glucose concentration in normal and diabetic rats.加替沙星对正常及糖尿病大鼠血清葡萄糖浓度的影响。
Biol Pharm Bull. 2006 Mar;29(3):527-31. doi: 10.1248/bpb.29.527.
6
Severe hyperglycemia during renally adjusted gatifloxacin therapy.经肾脏调整剂量的加替沙星治疗期间出现严重高血糖症。
Ann Pharmacother. 2005 Jul-Aug;39(7-8):1349-52. doi: 10.1345/aph.1E679. Epub 2005 Jun 7.
7
Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K+ channels.氟喹诺酮类药物对胰岛素分泌及β细胞ATP敏感性钾通道的影响。
Eur J Pharmacol. 2004 Aug 16;497(1):111-7. doi: 10.1016/j.ejphar.2004.06.032.
8
Hypoglycemia and hyperglycemia associated with gatifloxacin use in elderly patients.老年患者使用加替沙星相关的低血糖和高血糖症。
J Am Board Fam Pract. 2003 Sep-Oct;16(5):455-7. doi: 10.3122/jabfm.16.5.455.
9
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Clin Infect Dis. 2000 Aug;31 Suppl 2:S51-8. doi: 10.1086/314061.
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