Yun Haesun, Kim Daijin, Kim Soyeon, Kang Sujin, Jeong Seunghee, Cheon Yonghoon, Joe Keunho, Gwon Do-Hoon, Cho Sung-Nam, Jee Youngmee
Division of Enteric and Hepatitis viruses, Center for Infections Disease, Korea National Institute of Health, Seoul, Korea.
J Med Virol. 2008 Sep;80(9):1570-5. doi: 10.1002/jmv.21255.
Although intravenous drug users are a well-known route of hepatitis C virus (HCV) and hepatitis B virus (HBV) transmission, there is no data on the prevalence of HBV and HCV infection among intravenous drug users in Korea. In order to describe the prevalence of HBV and HCV infection, and to determine HCV genotypes in the population, serum samples were collected from 107 intravenous drug users during 2005-2006. Fifty-seven percent (n = 61) were HCV RNA positive and 51% (n = 55) were HBV DNA positive. Co-infection of HBV and HCV were found in 23% (n = 25). HCV genotypes 1b, 2a/2c, 2, 2b, and 3a were found in 38% (n = 23), 44% (n = 27), 8% (n = 5), 2% (n = 1), and 3% (n = 2), respectively. Moreover, mixed infections of genotypes 1b and 2a/2c were found in 5% (n = 3). When the number of patients with HCV genotype 1b compared with that of patients with genotype 2a/2c, HBV DNA titer was not significantly different by independent t-test (t = -0.881, P = 0.392 > 0.05) between the two patient groups. These results suggest that the prevalence of HBV and HCV infection among intravenous drug users is high showing over 50% in Korea and a strategic prevention program should be performed in this group to prevent further infection into local community.
尽管静脉注射吸毒者是丙型肝炎病毒（HCV）和乙型肝炎病毒（HBV）传播的一个众所周知的途径，但韩国尚无关于静脉注射吸毒者中HBV和HCV感染率的数据。为了描述HBV和HCV感染率，并确定该人群中的HCV基因型，于2005 - 2006年期间从107名静脉注射吸毒者中采集了血清样本。57%（n = 61）的人HCV RNA呈阳性，51%（n = 55）的人HBV DNA呈阳性。发现23%（n = 25）的人同时感染了HBV和HCV。分别在38%（n = 23）、44%（n = 27）、8%（n = 5）、2%（n = 1）和3%（n = 2）的人中发现了HCV基因型1b、2a/2c、2、2b和3a。此外，在5%（n = 3）的人中发现了基因型1b和2a/2c的混合感染。当比较HCV基因型1b患者与基因型2a/2c患者的数量时，两组患者之间通过独立t检验（t = -0.881，P = 0.392 > 0.05），HBV DNA滴度无显著差异。这些结果表明，韩国静脉注射吸毒者中HBV和HCV感染率很高，超过50%，应针对该群体实施一项战略预防计划，以防止进一步感染当地社区。
