Ancora Gina, Maranella Eugenia, Locatelli Chiara, Pierantoni Luca, Faldella Giacomo
Institute of Neonatology, University of Bologna, Via Massarenti 11, Bologna, Italy.
Brain Dev. 2009 Jun;31(6):442-4. doi: 10.1016/j.braindev.2008.06.003. Epub 2008 Jul 22.
Amplitude integrated EEG (aEEG) and Near Infrared Spectroscopy (NIRS) were applied in a newborn with a moderate hypoxic-ischemic encephalopathy before, during and after brain cooling. At 2h of life a selective head cooling with mild systemic hypothermia was started and maintained for 72h. aEEG background pattern improved from severely abnormal to normal during the first 17h of life. NIRS revealed a reduction in cerebral blood volume (CBV) during hypothermia that recovered during the rewarming period, whereas brain oxygenation remained stable. As brain cooling is supposed to reduce delayed hyperemia and help to maintain neuronal metabolism following cerebral insults, aEEG and NIRS monitoring may be useful during hypothermic treatment in order to document changes in CBV and brain oxygenation possibly reflecting the efficacy of hypothermia.
在一名患有中度缺氧缺血性脑病的新生儿脑降温前、降温和复温过程中，应用了振幅整合脑电图（aEEG）和近红外光谱（NIRS）技术。出生2小时时开始进行选择性头部降温并伴有轻度全身低温，持续72小时。出生后前17小时内，aEEG背景模式从严重异常改善为正常。NIRS显示低温期间脑血容量（CBV）减少，复温期恢复，而脑氧合保持稳定。由于脑降温被认为可减少迟发性充血并有助于在脑损伤后维持神经元代谢，aEEG和NIRS监测在低温治疗期间可能有用，以便记录CBV和脑氧合的变化，这些变化可能反映了低温治疗的效果。
