Gorbach Alexander M, Wang Hengliang, Elster Eric
National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Building 13, Room 3N-11, Bethesda, MD 20892-5766, USA.
Philos Trans A Math Phys Eng Sci. 2008 Oct 13;366(1880):3633-47. doi: 10.1098/rsta.2008.0117.
A high-resolution infrared (IR) camera was used to assess rhythmicity in localized renal blood flow, including the extent of regions containing nephrons with spontaneous oscillations in their individual blood flow. The IR imaging was able to follow changes in rat renal perfusion during baseline conditions, during occlusion of the main renal artery and during the administration of either saline or papaverine. Concurrent recordings were made of tubular pressure in superficial nephrons. Spontaneous vascular oscillations centred around 0.02-0.05 Hz and approximately 0.01 Hz could be detected reproducibly by IR imaging. Their spectral characteristics and their response to papaverine were in line with tubular pressure measurements. The intensity of and synchrony between thermal signals from different local areas of the kidney may allow, after surgical exposure, non-invasive imaging of functional clusters involved in renal cortical blood flow. Through visualization of the spatial extent of thermal oscillations, IR imaging holds promise in assessing kidney autoregulatory mechanisms.
使用高分辨率红外（IR）相机评估局部肾血流的节律性，包括含有单个血流具有自发振荡的肾单位的区域范围。红外成像能够跟踪大鼠在基线条件下、主肾动脉闭塞期间以及给予生理盐水或罂粟碱期间的肾灌注变化。同时记录浅表肾单位的肾小管压力。通过红外成像可重复检测到以0.02 - 0.05赫兹和大约0.01赫兹为中心的自发血管振荡。它们的光谱特征及其对罂粟碱的反应与肾小管压力测量结果一致。肾脏不同局部区域热信号之间的强度和同步性，在手术暴露后，可能允许对参与肾皮质血流的功能簇进行无创成像。通过可视化热振荡的空间范围，红外成像在评估肾脏自身调节机制方面具有前景。
