髓样细胞样转录本2（TLT-2）上表达的触发受体是B7-H3的反受体，可增强T细胞反应。
Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses.
作者信息
Hashiguchi Masaaki, Kobori Hiroko, Ritprajak Patcharee, Kamimura Yosuke, Kozono Haruo, Azuma Miyuki
机构信息
Department of Molecular Immunology, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
出版信息
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10495-500. doi: 10.1073/pnas.0802423105. Epub 2008 Jul 23.
Abstract
The B7 family member B7-H3 (CD276) plays important roles in immune responses. However, the function of B7-H3 remains controversial. We found that murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TLT-2 was expressed on CD8(+) T cells constitutively and on activated CD4(+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8(+) T cells. Transduction of TLT-2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. Blockade of the B7-H3:TLT-2 pathway with a mAb against B7-H3 or TLT-2 efficiently inhibited contact hypersensitivity responses. Our results demonstrate a direct interaction between B7-H3 and TLT-2 that preferentially enhances CD8(+) T cell activation.
摘要
B7家族成员B7-H3（CD276）在免疫反应中发挥重要作用。然而，B7-H3的功能仍存在争议。我们发现小鼠B7-H3特异性结合髓系细胞上表达的触发受体（TREM）样转录本2（TLT-2，TREML2）。TLT-2在CD8(+) T细胞上组成性表达，在活化的CD4(+) T细胞上也有表达。用B7-H3转染体刺激优先上调CD8(+) T细胞的增殖和IFN-γ产生。将TLT-2转导至T细胞中可通过与B7-H3相互作用增强IL-2和IFN-γ产生。用抗B7-H3或TLT-2的单克隆抗体阻断B7-H3:TLT-2途径可有效抑制接触性超敏反应。我们的结果证明了B7-H3与TLT-2之间的直接相互作用，这种相互作用优先增强CD8(+) T细胞活化。
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