Re: High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphatic leukemia.
作者信息
Cohen Ian J
出版信息
Blood. 2008 Aug 1;112(3):910. doi: 10.1182/blood-2008-04-150870.
Abstract
摘要
相似文献
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Re: High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphatic leukemia.关于：初发急性淋巴细胞白血病首次复发儿童中高剂量与中剂量甲氨蝶呤的比较。
Blood. 2008 Aug 1;112(3):910. doi: 10.1182/blood-2008-04-150870.
2
Anti-folate resistance in leukemia: treatment with "high-dose" methotrexate and citrovorum factor.
Cancer Treat Rev. 1975 Sep;2(3):215-24. doi: 10.1016/s0305-7372(75)80004-1.
3
Intermediate dose methotrexate (IDM) in childhood acute lymphocytic leukemia in Norway. Preliminary results of a national treatment program.
Acta Paediatr Scand. 1981 Jan;70(1):73-9. doi: 10.1111/j.1651-2227.1981.tb07176.x.
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[High dose methotrexate with citrovorum factor rescue therapy. (2) Measurement of methotrexate and its major metabolite, 7-hydroxymethotrexate in cerebrospinal fluid by high pressure liquid chromatography].[大剂量甲氨蝶呤联合亚叶酸钙解救疗法。（2）用高压液相色谱法测定脑脊液中甲氨蝶呤及其主要代谢物7-羟基甲氨蝶呤]
Nihon Gan Chiryo Gakkai Shi. 1983 Jun 20;18(4):889-95.
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Prolonged intravenous methotrexate therapy in the treatment of acute leukemia and solid tumors.甲氨蝶呤静脉延长疗法治疗急性白血病和实体瘤
Cancer Res. 1970 Aug;30(8):2132-8.
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Clinical pharmacodynamics of high-dose methotrexate in acute lymphocytic leukemia. Identification of a relation between concentration and effect.大剂量甲氨蝶呤在急性淋巴细胞白血病中的临床药效学。浓度与效应关系的确定。
N Engl J Med. 1986 Feb 20;314(8):471-7. doi: 10.1056/NEJM198602203140803.
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New approaches to chemotherapy with folate antagonists: use of leucovorin "rescue" and enzymic folate depletion.
Ann N Y Acad Sci. 1971 Nov 30;186:486-95.
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Methotrexate in the plasma and cerebrospinal fluid of children treated with intermediate dose methotrexate.接受中等剂量甲氨蝶呤治疗的儿童血浆和脑脊液中的甲氨蝶呤
Acta Paediatr Scand. 1981 Sep;70(5):615-8. doi: 10.1111/j.1651-2227.1981.tb05755.x.
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Sequential use of methotrexate, folinic acid, and cytosine arabinoside in the treatment of acute leukemia.甲氨蝶呤、亚叶酸钙和阿糖胞苷序贯用于治疗急性白血病。
Eur J Cancer (1965). 1976 Aug;12(8):617-23. doi: 10.1016/0014-2964(76)90187-0.
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Toxic and therapeutic effects of methotrexate-folinic acid (Leucovorin) in advanced cancer and leukemia.甲氨蝶呤 - 亚叶酸（甲酰四氢叶酸）在晚期癌症和白血病中的毒性及治疗作用。
Cancer. 1971 Oct;28(4):894-901. doi: 10.1002/1097-0142(1971)28:4<894::aid-cncr2820280412>3.0.co;2-i.
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Comment on: Dose adjustment strategy for high dose methotrexate-induced toxicities in pediatric acute lymphoblastic leukemia: based on population PK analysis and exposure toxicity relationship.评论：儿童急性淋巴细胞白血病中高剂量甲氨蝶呤诱导毒性的剂量调整策略：基于群体药代动力学分析和暴露-毒性关系
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In vivo response to methotrexate forecasts outcome of acute lymphoblastic leukemia and has a distinct gene expression profile.甲氨蝶呤的体内反应可预测急性淋巴细胞白血病的预后，并具有独特的基因表达谱。
PLoS Med. 2008 Apr 15;5(4):e83. doi: 10.1371/journal.pmed.0050083.
2
High-dose compared with intermediate-dose methotrexate in children with a first relapse of acute lymphoblastic leukemia.高剂量与中剂量甲氨蝶呤用于急性淋巴细胞白血病首次复发儿童的比较。
Blood. 2008 Mar 1;111(5):2573-80. doi: 10.1182/blood-2007-07-102525. Epub 2007 Dec 18.
3
High leucovorin doses during high-dose methotrexate treatment may reduce the cure rate in childhood acute lymphoblastic leukemia.在大剂量甲氨蝶呤治疗期间使用高剂量亚叶酸可能会降低儿童急性淋巴细胞白血病的治愈率。
Leukemia. 2006 Nov;20(11):1955-62. doi: 10.1038/sj.leu.2404404. Epub 2006 Sep 21.
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Comparison of long-term neurocognitive outcomes in young children with acute lymphoblastic leukemia treated with cranial radiation or high-dose or very high-dose intravenous methotrexate.接受头颅放疗或高剂量或极高剂量静脉注射甲氨蝶呤治疗的急性淋巴细胞白血病幼儿的长期神经认知结局比较。
J Clin Oncol. 2006 Aug 20;24(24):3858-64. doi: 10.1200/JCO.2006.05.9055.
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Defining the appropriate dosage of folinic acid after high-dose methotrexate for childhood acute lymphatic leukemia that will prevent neurotoxicity without rescuing malignant cells in the central nervous system.确定大剂量甲氨蝶呤治疗儿童急性淋巴细胞白血病后亚叶酸的合适剂量，该剂量既能预防神经毒性，又不会挽救中枢神经系统中的恶性细胞。
J Pediatr Hematol Oncol. 2004 Mar;26(3):156-63. doi: 10.1097/00043426-200403000-00004.
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Effect of protracted high-dose L-asparaginase given as a second exposure in a Berlin-Frankfurt-Münster-based treatment: results of the randomized 9102 intermediate-risk childhood acute lymphoblastic leukemia study--a report from the Associazione Italiana Ematologia Oncologia Pediatrica.在基于柏林-法兰克福-明斯特方案的治疗中，第二次给予长时间高剂量L-天冬酰胺酶的效果：随机9102中危儿童急性淋巴细胞白血病研究结果——来自意大利儿科学血液学肿瘤学协会的报告
J Clin Oncol. 2001 Mar 1;19(5):1297-303. doi: 10.1200/JCO.2001.19.5.1297.
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Acute neurotoxicity in children with B-precursor acute lymphoid leukemia: an association with intermediate-dose intravenous methotrexate and intrathecal triple therapy--a Pediatric Oncology Group study.B 前体急性淋巴细胞白血病患儿的急性神经毒性：与中剂量静脉注射甲氨蝶呤和鞘内三联疗法的关联——一项儿科肿瘤学组研究
J Clin Oncol. 1998 May;16(5):1712-22. doi: 10.1200/JCO.1998.16.5.1712.
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Extended triple intrathecal chemotherapy trial for prevention of CNS relapse in good-risk and poor-risk patients with B-progenitor acute lymphoblastic leukemia: a Pediatric Oncology Group study.用于预防B祖细胞急性淋巴细胞白血病低危和高危患者中枢神经系统复发的鞘内三联化疗延长试验：一项儿科肿瘤学组研究
J Clin Oncol. 1993 May;11(5):839-49. doi: 10.1200/JCO.1993.11.5.839.
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Cerebrospinal fluid drug levels of leukemic children receiving intravenous 5 g/m2 methotrexate.接受静脉注射5 g/m²甲氨蝶呤的白血病儿童的脑脊液药物水平。
Leuk Lymphoma. 1994 Jun;14(1-2):141-4. doi: 10.3109/10428199409049660.
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How much is too much? Folinic acid rescue dose in children with acute lymphoblastic leukaemia.
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