Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy.
作者信息
Ingle Lee, Rigby Alan S, Carroll Sean, Butterly Ron, King Rod F, Cooke Carlton B, Cleland John Gjf, Clark Andrew L
机构信息
Carnegie Research Institute, Leeds Metropolitan University, Beckett's Park Campus, Leeds.
出版信息
Exp Clin Cardiol. 2007 Spring;12(1):46-7.
BACKGROUND
Increasing body mass index, cholesterol and body fat are associated with a better prognosis in patients with left ventricular systolic dysfunction (LVSD). Beta-blocker usage is associated with changes in body composition and increased body fat. The present study investigated 12-month changes in body composition in patients with LVSD initiated on beta-blocker therapy.
METHODS
The relation between beta-blocker use and body composition was evaluated in 91 patients (75% male) with LVSD. Body composition was assessed by bioelectrical impedance.
RESULTS
Seventeen patients died during the study period. There was no statistical difference among beta-blocker usage, beta-blocker type, or changes in body fat, basal metabolic rate, impedance, fat-free mass, fat mass and total body water. There were no significant differences between any of these measures and beta-blocker usage.
CONCLUSION
After 12 months, changes in body composition were not found to be influenced by initiation of beta-blocker therapy in patients with LVSD.
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