Takada Hiroki, Nakazawa Takahiro, Ohara Hirotaka, Ando Tomoaki, Hayashi Kazuki, Naito Itaru, Okumura Fumihiro, Tanaka Hajime, Yamada Tamaki, Takahashi Satoru, Joh Takashi
Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467-8601, Japan.
Dig Dis Sci. 2009 Apr;54(4):793-801. doi: 10.1007/s10620-008-0418-4. Epub 2008 Jul 24.
The aim of the present study was to determine the potential for pancreatic calcification in autoimmune pancreatitis by investigating osteopontin and CD44 expression.
Human pancreatic tissues in normal pancreas, chronic pancreatitis, and autoimmune pancreatitis were obtained from the surgical specimens of 42 patients. Pancreatic tissues from male Wistar Bonn/Kobori rats were also used as an animal autoimmune pancreatitis model.
The incidences of osteopontin expression in centroacinar cells in chronic pancreatitis with calcification and in autoimmune pancreatitis were significantly greater than that in normal pancreas (P < 0.05). Some cases of chronic pancreatitis and autoimmune pancreatitis expressed CD44 in centroacinar cells and ductal cells. In male Wistar Bonn/Kobori rats, the inflammatory area and percentage of osteopontin-CD44-positive cells increased with advancing age (P < 0.01 or 0.05).
These results suggest that autoimmune pancreatitis has the potential for pancreatic calcification over a long-term clinical course.
本研究旨在通过调查骨桥蛋白和CD44的表达来确定自身免疫性胰腺炎中胰腺钙化的可能性。
从42例患者的手术标本中获取正常胰腺、慢性胰腺炎和自身免疫性胰腺炎的人体胰腺组织。雄性Wistar Bonn/Kobori大鼠的胰腺组织也用作动物自身免疫性胰腺炎模型。
伴有钙化的慢性胰腺炎和自身免疫性胰腺炎中腺泡中心细胞骨桥蛋白表达的发生率显著高于正常胰腺（P < 0.05）。一些慢性胰腺炎和自身免疫性胰腺炎病例在腺泡中心细胞和导管细胞中表达CD44。在雄性Wistar Bonn/Kobori大鼠中，炎症区域和骨桥蛋白-CD44阳性细胞的百分比随年龄增长而增加（P < 0.01或0.05）。
这些结果表明，自身免疫性胰腺炎在长期临床病程中有胰腺钙化的可能性。
