Kurts Christian
Institute for Molecular Medicine and Experimental Immunology (IMMEI), University of Bonn, Bonn, Germany.
Eur J Immunol. 2008 Aug;38(8):2072-5. doi: 10.1002/eji.200838645.
The induction of robust CD4(+) and CD8(+) T cell responses is a central aim in antiviral and anticancer vaccination. To this end, dendritic cells (DC) need to capture the vaccine, process and present it on MHC class I and II molecules. The mechanisms by which DC acquire antigen predetermine the quantity and quality of the ensuing T cell activation. In this issue of the European Journal of Immunology, it is demonstrated that targeting antigen towards CD11c, an integrin expressed preferentially by murine DC, facilitates efficient CD4(+) and CD8(+) T cell activation. The underlying mechanisms involve efficient antigen delivery into the marginal zone and T/DC zone of the spleen. This commentary discusses these findings in the context of current knowledge on antigen presentation.
诱导强大的CD4(+)和CD8(+) T细胞反应是抗病毒和抗癌疫苗接种的核心目标。为此，树突状细胞（DC）需要捕获疫苗、进行加工并将其呈递于MHC I类和II类分子上。DC获取抗原的机制预先决定了随后T细胞活化的数量和质量。在本期《欧洲免疫学杂志》中，研究表明将抗原靶向CD11c（一种小鼠DC优先表达的整合素）可促进高效的CD4(+)和CD8(+) T细胞活化。潜在机制包括将抗原有效递送至脾脏的边缘区和T/DC区。本述评在当前抗原呈递知识的背景下讨论了这些发现。
