人类脑挫伤后的胶质细胞肿胀：一项超微结构研究。

Bullock R, Maxwell W L, Graham D I, Teasdale G M, Adams J H

Department of Neurosurgery, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK.

J Neurol Neurosurg Psychiatry. 1991 May;54(5):427-34. doi: 10.1136/jnnp.54.5.427.

The ultrastructural features of cerebral contusion seen three hours to 11 days after head injury were studied in 18 patients undergoing surgery. Massive astrocytic swelling ("cytotoxic" oedema) was seen three hours to three days after injury, maximal in perivascular foot processes, and compressing some of the underlying capillaries. The tight junctions were not disrupted. Neuronal damage was most marked three to 11 days after injury. The pathophysiological mechanisms leading to oedema formation and neuronal degeneration are discussed.

对18例接受手术的患者研究了头部受伤后3小时至11天所见脑挫伤的超微结构特征。受伤后3小时至3天可见大量星形细胞肿胀（“细胞毒性”水肿），在血管周围足突中最为明显，并压迫一些深层毛细血管。紧密连接未被破坏。神经元损伤在受伤后3至11天最为明显。讨论了导致水肿形成和神经元变性的病理生理机制。