Obrzut Bogdan, Obrzut Marzanna, Skret-Magierło Joanna, Skret Andrzej, Ulman Dariusz, Król Piotr, Zmuda Marcin
Institute of Nursing and Obstetrics, Faculty of Medicine, University of Rzeszów.
Ginekol Pol. 2008 Jun;79(6):404-9.
The aim of the study was to evaluate the value of intraoperative assessment of depth of myometrial invasion in patients with FIGO stage I of the endometrial carcinoma.
A total number of 112 patients with FIGO stage I of the endometrial carcinoma undergoing surgery were enrolled in the study. All patients had undergone intraoperative assessment of the depth of myometrial invasion performed by a surgeon. The depth was determined as more or less than 50% of myometrial thickness according to FIGO classification. Gross visual estimation of the depth of myometrial invasion at the time of the operation was compared with the final histopathological report. Sensitivity, specificity and positive and negative predictive values of the method were determined by means of statistical analyses.
The depth of the myometrial invasion was accurately determined by the surgeon in 82.1% of cases. Sensitivity and specificity were 68% and 82.1%, respectively. The accurate prediction rate of the myometrial invasion in the group of patients with well differentiated (G1) endometrial carcinoma was higher (88.4%) than in group with moderately and low differentiated tumour (78.3%).
The accuracy of macroscopic evaluation of myometrial invasion is high and reaches up to 82.1%. The accurate determination rate increases if the differentiation of tumour is higher.
本研究旨在评估子宫内膜癌国际妇产科联盟（FIGO）Ⅰ期患者术中子宫肌层浸润深度评估的价值。
本研究纳入了112例行手术治疗的FIGOⅠ期子宫内膜癌患者。所有患者均由外科医生进行了术中子宫肌层浸润深度评估。根据FIGO分类，浸润深度被确定为子宫肌层厚度的50%以上或以下。将手术时子宫肌层浸润深度的大体视觉估计与最终组织病理学报告进行比较。通过统计分析确定该方法的敏感性、特异性以及阳性和阴性预测值。
外科医生在82.1%的病例中准确确定了子宫肌层浸润深度。敏感性和特异性分别为68%和82.1%。高分化（G1）子宫内膜癌患者组子宫肌层浸润的准确预测率（88.4%）高于中低分化肿瘤组（78.3%）。
子宫肌层浸润的宏观评估准确性较高，可达82.1%。肿瘤分化程度越高，准确确定率越高。
